I had a period every month but with a deviation of maybe two weeks. My gynecologist gave me the combi in the morning and the luteal in the evening (for the period and trying to conceive), but my cycle did change, but I still didn't have a consistent day, and besides, it cost a lot of money every 20 days!!!! As soon as I took it in the evening, after 20 minutes, I simply had to go to sleep because I couldn't handle it, and if I took it late at night, the next day I was a vegetable. Now I decided to try the plus because in general, inofert products are very good and natural!!!