I have been using Microsoft ergonomic keyboards for over 10 years (ergonomic 7000, 4000, etc.). It is the best ergonomic keyboard that the company has released and one of the best overall. Because my work involves a lot of text editing, I have never had any issues with wrist strain using Microsoft ergonomic keyboards, including this one.
In terms of positives: the key press is excellent, the design is original and top-notch. It has a compact size, perfect for small offices or limited space. Personally, I don't use the detachable numeric keypad, so I find the smaller length of the keyboard extremely convenient. Its ergonomic design and support are ideal for protecting the wrists from strain, especially when typing for long hours. The laptop-style keys are quiet, in fact, I would say they are some of the quietest I have used. The key spacing is small. Compared to previous keyboards, I have noticed a significant difference in typing speed, key press force, and noise. I am familiar with touch typing, and with this keyboard, I can type faster, make fewer mistakes, and it is definitely quieter. It takes two small AAA batteries, which definitely last for over a year. It doesn't have an on/off switch, but it doesn't really need one.
As for the negatives: it doesn't have LED backlit keys. Since I am familiar with touch typing, this doesn't bother me because I don't look at the keys while typing. Due to its ergonomic design, it is targeted towards those who are familiar with touch typing. If you look at the keys while typing, it's better to look for something else because you will get confused with this keyboard. It is not a keyboard for gamers, but it is almost exclusively aimed at people who type a lot. The arrow keys are not as convenient to use and I often confuse them with other keys because they don't stand out and there is no spacing between them and the other keys, they are somewhat cramped. There is no indicator or light on the keyboard to show when the CAPS LOCK is pressed. A significant negative is that the wrist support cushion, which used to be leather in previous Microsoft ergonomic keyboards, is now somewhat fabric-like or suede, which results in it getting dirty from hands and friction. If you don't clean it constantly with, for example, wet wipes, it starts to look faded in the areas where the wrists touch. Microsoft provides minimal support for its keyboards on Mac computers, therefore, without drivers, some secondary functions and keys do not work on Mac computers. For the same reason, you cannot customize the functions of various keys on Mac. In general, it has very limited customization options. Another downside is that it doesn't use Bluetooth, only the Microsoft receiver at 2.4 GHz. Lastly, the F1, F2, etc. keys are not regular-sized, they are smaller and have a different shape, and they will likely start to stick after a certain point. Essentially, they are not keys but buttons. Compared to most keyboards, they are small and not user-friendly. If you use them frequently, their use may become annoying. I am starting to have a similar issue with the ESCAPE key (same shape as the F1, F2, etc.), which often gets stuck.
I don't use the mouse and I don't have a clear opinion on it because I have a different one from Logitech, but I can confirm that even though it is large, it is ergonomic and comfortable. Overall, it is a honest and premium product that justifies its high price compared to other ergonomic keyboards, especially since it includes a mouse. I have been using it for three years already and I am completely satisfied.
UPDATE 21/3/2021: After 5 years of use, this keyboard still accompanies me in my daily life. It remains one of the best ergonomic keyboards that have been released, but now it faces stronger competition (Logitech Ergo K860) as it used to be almost unrivaled. It has encountered some minor issues, mainly with the ESCAPE key, which often gets stuck and requires me to press it a couple of times a day at least to unstick it. The wrist rest has not gotten dirty (because I clean it regularly every 2-3 days), but it does show signs of aging. It remains durable and comfortable, without fading in certain areas, but its texture has changed somewhat due to friction, giving it a rubbery feel rather than a matte fabric feel. The fabric surface shows signs of wear, but not where the hands rest (as one would expect), but rather at the lower edge. The truth is that it requires quite a bit of attention as it gets easily dirty. Occasionally, I notice some very minor typing delays, which are related to interference in the 2.4 GHz frequency. It is not something widespread or common, nor is it something rare. Due to frequent use, I believe that the sensation of certain keys is gradually affected, which is expected but not to the point of being bothersome. I believe that it was worth the money, and I have not regretted it for a moment. It has been a faithful worker, but now I want more from a keyboard (Bluetooth, ability to connect simultaneously to a laptop, support for Mac computers, key customization, better drivers), so I see myself looking for a replacement.