I have combined it with R5 7600x, and G Skill Trident 32GB at 6400 (32CL) and Samsung 990 Pro.
1) I don't know if it's a problem with the mobo or the CPU, but I had to clock the RAM at 6000 because the PC wouldn't even boot. (It's unacceptable for something like this to happen in 2025)
2) It has incredibly slow load times; in my previous setup, I had a B450 with R5 3600x and a Kingston NVMe 3rd generation, and I booted the PC in 6-7 seconds, now it takes 30+. The problem persists after many BIOS updates

Recently purchased so early for a final evaluation. It came with a very outdated bios version, however, it did not cause any problems in installing Windows 11. Updating the bios was not difficult.

It is pleasant to note that with the default ("optimized") bios settings (with Memory Context Restore and Power Down settings set to auto), the startup time, from shutdown always, has stabilized at around 10 seconds (correction: 11 sec until Windows loading starts). However, I note that
a) The DDR5 I am using (Kingston Fury KF560C36BBEA-8) is included in the motherboard's compatibility list,
b) The DDR5 runs at standard speed (4800MHz) and not at 6000MHz. I will leave it like this because the expo and xmp profiles do not offer a significant speed increase to justify the difficulty they introduce to the memory controller's operation. I suggest you do the same on any am5 m/b, otherwise you are overclocking the memory controller (let's not forget that memory training is already quite difficult with DDR5). It is not worth the trouble and the reduction in lifespan, I think.

The S3 (legacy sleep mode) works normally, as well as hibernate, as long as it is enabled from the BIOS.

As usual for Asus, two unknown ACPI devices appear in the Device Manager. I probably won't bother with them further, they are probably some irrelevant sensors or the rgb led controller. Edit: I downloaded the latest AMD chipset driver set from the Asus website, installed it, and now the unknown devices are no longer present.