The toe separators reduce pressure and friction between the toes. They provide relief from irritation and help align the joint.

Metatarsalgia is the pain in the heads of the metatarsal bones and can be caused by many pathological conditions with different causes and treatments. It is not considered a disease but a symptom.
The initial treatment includes rest and unloading of the limb, ice therapy, and compression bandaging of the foot. Applying ice packs to the area of intense pain for 20-25 minutes each time several times a day can help minimize inflammation. Painkillers also reduce pain, especially those with anti-inflammatory action and inflammation.
The use of orthotic insoles in the metatarsal area and special shoes can significantly relieve pain even during the acute initial phase.

In any case, consult your doctor.