•  TRIBUTIN is available in the form of coated, gastro-resistant tablets with controlled release. 
• The pharmaceutical technology used for the controlled release form has been studied to deliver the three active ingredients (butyric acid, fructo-oligosaccharides, and bifidobacteria) directly to the colon, where they can act effectively, contributing to the maintenance of the good condition of the epithelial cells of the colon, enhancing the cell cycle of the intestinal epithelium, and promoting the normalization of bowel movements with a consequent reduction of painful symptoms caused by the colon.
• Its composition is protected by Italian (No0001395328) and European (No 2289505) patents.

• Butyric acid is a short-chain fatty acid, naturally found as a minor component in the fat fraction of milk and its derivatives.
• In humans, it is a substance that is naturally formed in the large intestine as a result of the fermentation of dietary fibers.
• Clinical experience has shown that in patients with disturbances in cell balance in the large intestine, specifically in the ileocolic section, the intake of butyric acid leads to a remarkable improvement in symptoms such as diarrhea, abdominal pain, and general malaise.

It is the main energy source for the epithelial cells of the large intestine:

•  it stimulates their replacement and normal maturation and plays a significant "key" role in maintaining the integrity of the mucosa and in the healing process of intestinal lesions,
• it activates the reabsorption of water and sodium in the large intestine,
• it helps reduce intestinal pH, thus creating an inhospitable environment for the growth of pathogenic bacteria.

• They are the most beneficial bacteria found in the large intestine of adults and children. 
• These bacteria decrease with age and when health begins to decline. 
• The population of Bifidobacterium Bifidus bacteria that colonize the human intestine can be destroyed by many factors related to lifestyle, health, and environmental conditions.

The benefits of bifidobacteria intake are:

• The prevention of colonization of the intestine by hostile pathogenic bacteria and fungi, with which bifidobacteria compete for nutrients.
• The production of acetic acid and lactic acid, which lower the pH of the intestine and thus make the area inhospitable for other bacteria.
• The inhibition of bacteria that can convert nitrates from the diet into potentially dangerous nitrites.
• An adequate population of bifidobacteria can solve constipation problems and improve intestinal function.

• Fructo-oligosaccharides are complex carbohydrates, i.e., natural sugars in the form of polymers, found in small amounts in various plants. 
• Together with other starchy-type oligosaccharides like inulin, fructo-oligosaccharides are almost indigestible. They are widely used for their “prebiotic” effect, which means they serve as the nutrients for various bacterial populations that make up our gut flora.
• Fructo-oligosaccharides enhance the ability of lactic enzymes (probiotics) to promote normal intestinal function, especially when combined with highly beneficial bacteria such as bifidobacteria.
• In addition to improving digestion and absorption, fructo-oligosaccharides help prevent intestinal disorders such as constipation, colitis, or diarrhea.

• The dosage should be determined by the attending physician, taking into account the different individual needs of the patient.
• The usual dosage is 1 or 2 tablets daily, preferably on an empty stomach.

Precautions:

• The product should be used under medical supervision. The product is not indicated as the sole source of nutrition.
• TRIBUTIN tablets should not be chewed or broken.
• Swallow whole.
• Store the product in a cool, dry place.