This is perhaps the only option we have in the domestic market for a decent Coq10 that is not overpriced. For purchases from abroad, there are several very good options, but not in the domestic market. It is generally an expensive supplement, but in the domestic market, we see exorbitant prices or small quantities.
Some things about Coq10.

- Anything below 100mg personally I wouldn't bother with at all. Also, anything that is priced in a way that doesn't allow me to use it consistently. Generally, I want to have the same relationship with Coq10 as I do with something like omega-3 - regular use for long-term benefits. We want to make an intervention, we will see why in a bit.
- Coq10 is a fat-soluble substance, I take it with a meal of the day, just like I do with vitamin D.
- From Coq10, I have felt only a subtle sense of internal stability, so to speak, which could have been a placebo. It's difficult to describe these things. Anyway, if we don't perceive any particular action, that's normal.
- It has the double benefit of being a very powerful antioxidant (hundreds of times more powerful than vitamin C) and participating in a very basic process of energy production in our mitochondria. Our body produces it. But after the age of 35, the concentration in tissues starts to decrease, especially in organs like the heart. So, 35-40 is a good age to turn to it, earlier probably doesn't make sense.
- There is the myth of the "best", more absorbable ubiquinol (you will see it as a much more expensive Coq10). This probably comes from the observation that for Coq10 to be absorbed from the small intestine, it is converted into its 'active' form, ubiquinol. So by giving it as is, theoretically, I help my body avoid this conversion. Different studies have shown that there is no substantial difference, but also that there is better absorption (especially in older people) - which, however, the difference in price and the amount of mg I can take probably negates.
- The truth is that our body constantly recycles Coq10 from one form to another, from the oxidized form (ubiquinone) to the concentrated form (ubiquinol) and vice versa. If we take ubiquinol, our body will convert it to ubiquinone anyway - very early on to pass it to the lymph from the small intestine. The only benefit is somewhat, perhaps better absorption in the first stage.
- We understand that if we take 100mg ubiquinol (a very expensive supplement) for 2-3 months a year and on the other hand, 100 or even 200mg ubiquinone for a year - the benefits will be much greater in the second case.
- Here we come to the use we want to achieve. With Coq10, we want to raise its levels in the blood with consistent intake (to achieve what we call a pharmacologically stable state) and keep it there for as long as possible. We saturate our organism and let it absorb what it needs to start replenishing Coq10 levels in our cells.
- Two of the major studies with this (Q-Symbio and Kisel-10), one in people with chronic heart disease, the other in elderly individuals with an average age of 78, showed very significant benefits - a reduction of around 55% in both cases of the risk of death from cardiovascular diseases. But it was not used passively. And in both studies, ubiquinone was used incidentally, 3x100mg per day for two years in one case, 200mg/day for four years in the other, a sufficient amount for a long period of time.